In [27]: x = np.arange(16).reshape((4,2,2))
In [28]: x.reshape(2,2,2,2).swapaxes(1,2).reshape(4,-1)
Out[28]:
array([[ 0, 1, 4, 5],
[ 2, 3, 6, 7],
[ 8, 9, 12, 13],
[10, 11, 14, 15]])
I’ve posted more general functions for reshaping/unshaping arrays into blocks, here.