Upgrade to the very latest pip and setuptools; install twine:
pip install -U pip setuptools twine
Edit ~/.pypirc
and comment out or remove repository
:
[pypi]
#repository:https://pypi.python.org/pypi
Use twine to upload your module to pypi from within the folder containing the module source, setup.py, and other files:
python setup.py sdist
twine upload dist/*
See https://packaging.python.org/guides/migrating-to-pypi-org/#uploading