Bitwise XOR of hexadecimal numbers

Whoa. You’re really over-complicating it by a very long distance. Try:

>>> print(hex(0x12ef ^ 0xabcd))
0xb922

You seem to be ignoring these handy facts, at least:

• Python has native support for hexadecimal integer literals, with the 0x prefix.
• “Hexadecimal” is just a presentation detail; the arithmetic is done in binary, and then the result is printed as hex.
• There is no connection between the format of the inputs (the hexadecimal literals) and the output, there is no such thing as a “hexadecimal number” in a Python variable.
• The hex() function can be used to convert any number into a hexadecimal string for display.

If you already have the numbers as strings, you can use the int() function to convert to numbers, by providing the expected base (16 for hexadecimal numbers):

>>> print(int("12ef", 16))
4874

So you can do two conversions, perform the XOR, and then convert back to hex:

>>> print(hex(int("12ef", 16) ^ int("abcd", 16)))
0xb922