AppDomain.CurrentDomain.BaseDirectory
is probably the most useful for accessing files whose location is relative to the application install directory.
In an ASP.NET application, this will be the application root directory, not the bin subfolder – which is probably what you usually want. In a client application, it will be the directory containing the main executable.
In a VSTO 2005 application, it will be the directory containing the VSTO managed assemblies for your application, not, say, the path to the Excel executable.
The others may return different directories depending on your environment – for example see @Vimvq1987’s answer.
CodeBase
is the place where a file was found and can be a URL beginning with http://. In which case Location
will probably be the assembly download cache. CodeBase is not guaranteed to be set for assemblies in the GAC.
UPDATE
These days (.NET Core, .NET Standard 1.3+ or .NET Framework 4.6+) it’s better to use AppContext.BaseDirectory
rather than AppDomain.CurrentDomain.BaseDirectory
. Both are equivalent, but multiple AppDomains are no longer supported.