Pandas is aware of the object datetime but when you use some of the import functions it is taken as a string. So what you need to do is make sure the column is set as the datetime type not as a string. Then you can make your query.
df['date'] = pd.to_datetime(df['date'])
df_masked = df[(df['date'] > datetime.date(2012,4,1)) & (df['date'] < datetime.date(2012,4,4))]