Improve subplot size/spacing with many subplots in matplotlib

Try using plt.tight_layout

As a quick example:

import matplotlib.pyplot as plt

fig, axes = plt.subplots(nrows=4, ncols=4)
fig.tight_layout() # Or equivalently,  "plt.tight_layout()"

plt.show()

Without Tight Layout

enter image description here

With Tight Layout
enter image description here

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