New in Windows 10 is dpiAwareness as well as dpiAware, so we need to update this example a bit. Now, it is fine because if dpiAwareness does not exist, then the settings will be inherited from dpiAware.
To enable DPI awareness in full, with the latest Win10 support (see Ref URL for other possible options), which includes ‘permonitor‘ and ‘permonitorv2‘, which I will use instead of ‘system’ because your question asks it.
<asmv3:application>
<asmv3:windowsSettings>
<dpiAware xmlns="http://schemas.microsoft.com/SMI/2005/WindowsSettings">true/pm</dpiAware> <!-- legacy -->
<dpiAwareness xmlns="http://schemas.microsoft.com/SMI/2016/WindowsSettings">permonitorv2,permonitor</dpiAwareness> <!-- falls back to pm if pmv2 is not available -->
</asmv3:windowsSettings>
</asmv3:application>
To disable, you’d do the opposite (no need for dpiAwareness
since we don’t support it):
<asmv3:application>
<asmv3:windowsSettings>
<dpiAware xmlns="http://schemas.microsoft.com/SMI/2005/WindowsSettings">unaware</dpiAware>
</asmv3:windowsSettings>
</asmv3:application>
Then there is even ‘gdiScaling’ if you happen to use GDI objects to paint some of your own stuff.
<asmv3:application>
<asmv3:windowsSettings>
<gdiScaling xmlns="http://schemas.microsoft.com/SMI/2017/WindowsSettings">true</gdiScaling>
</asmv3:windowsSettings>
</asmv3:application>
Reference: Microsoft on DPI Awareness as of latest Windows 10 build (also has tutorials on how to make your code DPI aware, even if it is a little tedious for larger projects)