Differences between .NET 4.0 and .NET 4.5 in High level in .NET

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What is new in .NET Framework 4.5 & What’s new and expected in .NET Framework 4.5:

  • Support for Windows Runtime
  • Support for Metro Style Applications
  • Support for Async Programming
  • Garbage Collector Improvements
  • Faster ASP.NET Startup
  • Better Data Access Support
  • WebSockets Support
  • Workflow Support – BCL Support

differences in ASP.NET in these frameworks

Compare What’s New in ASP.NET 4 and Visual Web Developer and What’s New in ASP.NET 4.5 and Visual Studio 11 Beta:

Asp.net 4.0

  • Web.config File Refactoring
  • Extensible Output Caching
  • Auto-Start Web Applications
  • Permanently Redirecting a Page
  • Shrinking Session State
  • Expanding the Range of Allowable URLs
  • Extensible Request Validation
  • Object Caching and Object Caching Extensibility
  • Extensible HTML, URL, and HTTP Header Encoding
  • Performance Monitoring for Individual Applications in a Single Worker Process
  • Multi-Targeting
  • etc

And for Asp.net 4.5 there is also a long list of improvements:

  • Asynchronously Reading and Writing HTTP Requests and Responses
  • Improvements to HttpRequest handling
  • Asynchronously flushing a response
  • Support for await and Task-Based Asynchronous Modules and Handlers

differences in C# also in these frameworks

Go Through C# 4.0 – New C# Features in the .NET Framework and What’s New for Visual C# in Visual Studio 11 Beta.

Edit:
The languages documentation for C# and VB breaking changes:

VB: Visual Basic Breaking Changes in Visual Studio 2012

C#: Visual C# Breaking Changes in Visual Studio 2012

Hope this help you get what are you looking for..

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