You should try SciPy. It has a bunch of useful scientific routines for example, “routines for computing integrals numerically, solving differential equations, optimization, and sparse matrices.” It uses the superfast optimized NumPy for its number crunching. See here for installing.
Note that spatial.distance.cosine computes the distance, and not the similarity. So, you must subtract the value from 1 to get the similarity.
from scipy import spatial
dataSetI = [3, 45, 7, 2]
dataSetII = [2, 54, 13, 15]
result = 1 - spatial.distance.cosine(dataSetI, dataSetII)