Use M2Crypto. Here’s how to verify for RSA and any other algorithm supported by OpenSSL:
pem = """-----BEGIN PUBLIC KEY-----
MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQDfG4IuFO2h/LdDNmonwGNw5srW
nUEWzoBrPRF1NM8LqpOMD45FAPtZ1NmPtHGo0BAS1UsyJEGXx0NPJ8Gw1z+huLrl
XnAVX5B4ec6cJfKKmpL/l94WhP2v8F3OGWrnaEX1mLMoxe124Pcfamt0SPCGkeal
VvXw13PLINE/YptjkQIDAQAB
-----END PUBLIC KEY-----""" # your example key
from M2Crypto import BIO, RSA, EVP
bio = BIO.MemoryBuffer(pem)
rsa = RSA.load_pub_key_bio(bio)
pubkey = EVP.PKey()
pubkey.assign_rsa(rsa)
# if you need a different digest than the default 'sha1':
pubkey.reset_context(md='sha1')
pubkey.verify_init()
pubkey.verify_update('test message')
assert pubkey.verify_final(signature) == 1