How do I (or can I) SELECT DISTINCT on multiple columns?

SELECT DISTINCT a,b,c FROM t

is roughly equivalent to:

SELECT a,b,c FROM t GROUP BY a,b,c

It’s a good idea to get used to the GROUP BY syntax, as it’s more powerful.

For your query, I’d do it like this:

UPDATE sales
SET status="ACTIVE"
WHERE id IN
(
    SELECT id
    FROM sales S
    INNER JOIN
    (
        SELECT saleprice, saledate
        FROM sales
        GROUP BY saleprice, saledate
        HAVING COUNT(*) = 1 
    ) T
    ON S.saleprice=T.saleprice AND s.saledate=T.saledate
 )